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Save a fortune on Levitra; COMPARISON SHOP
Internet pharmacies compete for your business to
drive down prices. Click Here to Comparison Shop For Levitra
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Buying Generic Levitra On The Internet
When you buy brand name Levitra on the internet expect to pay a lot more, about $10.00 per pill or more. Generic Levitra, can be obtained for as little as $2.00 per pill from countries with lax patent laws (such as India).
When you buy internet Levitra, there are lots of people
trying to rip you off. For instance, you may order Levitra
5mg, but they sell you 20mg tablets broken in half.
You get a little baggie of half-tablets and Levitra crumbs.
The best way to find a legitimate Levitra merchant is to go by word of mouth. Another technique is to visit the site and test out the customer service telephone number or customer service instant message chat.
Ask them a few questions such as:
- "When I buy the Levitra, where is it shipped from"
- "What is the expiration date?"
- "How long have you been in business?"
- "How long will it take for my pills to get here"
If they do not answer the customer service number, of they take too long to respond to your chat questions, go to a different site.
Who does this site recommend?
If you are looking for brand-name Levitra manufactured by Bayer Pharmaceuticals, without a prescription, I recommend AccessRx.com. They have been in business since 1999. They are located in the USA in Tempe Arizona. They offer overnight shipping.
They have a 24 hour telephone number for customer service. They even have licensed physicians and pharmacists on staff to answer your medical questions.
I can vouch for AccessRx.com because I am friends with AccessRx.com's director of Marketing, Richard Bernstein. Mr. Bernstein takes his business seriously and takes pride in his company's track record and reputation.
Their prices are higher than the generics but you are assured of getting brand-name, American, FDA-Approved Levitra and similar medicines delivered to your door in a couple of days without having to go to a doctor.
Levitra (Vardenafil) is a member of a family of
drugs called PDE5 Inhibitors.
Levitra Dose, Levitra Cost:
Levitra is available in tablet form in the following
strengths: 2.5mg, 5mg, 10mg and 20mg. Legitimate
internet pharmacies like RxUsa.com or Drugstore.com
charge $9.00 to $10.00 per Levitra 10mg pill
(the usual starting dose) when you buy 30 pills.
Maximum Dose Of Levitra
The maximum dose of Levitra is one pill
per day. The usual starting dose of Levitra
is 10mg once per day (60 minutes prior to sexual activity).
The dose can be titrated up to 20mg or down to 2.5mg
based on efficacy and side effects. Levitra can be taken
without regard to food.
How Does Levitra Work (Levitra Mechanism Of Action)
When an erection goes flaccid, you have PDE5 to thank.
Specialized penis tissue secretes a substance called cyclic
guanosine monophosphate (cGMP) in response to sexual
stimulation. The more cGMP available, the more durable
the erection. Levitra inhibits the PDE5 enzyme, preserving
cGMP levels, therefore aiding erection viability and durability.
Levitra Pharmacokinetics; Absorption, Onset, Bioavailability:
Levitra is rapidly absorbed from the bloodstream. It is
about 15% bioavailable. Levitra (vardenafil) is about 95%
bound to plasma protein. Maximum plasma concentration
of Levitra occurs between 30 minutes and 2 hours after you
take the pill.
The Levitra label states that you should take a pill
approximately 60 minutes before sexual activity.
Levitra Pharmacodymanics, Sise Effects, Metabolism
Levitra is mostly metabolized in the liver by an enzyme
known as CYP3A4 and to a lesser extent CYPC2. Levitra
breakdown products are excreted in the feces (91-95%)
and in the urine (2-6%).
If you are going to take Levitra, it is very important that
your doctor be aware if you have a liver condition
(such as cirrhosis) because you may need a special
dosage adjustment.
If you try to obtain Levitra on the internet, please make
sure that the person authorizing your prescription knows
the true status of your liver function.
Levitra Marketing:
When Levitra was launched, they tried to create a tough guy,
macho image for Levitra, as if to say that "even big strong
men experience difficulty getting and staying erect".
The ads were very "in your face".
The Levitra marketers used Mike Ditka, a chubby,
aging, macho, football player as a spokesman. They ran
a promotion whereby you could visit the Levitra website
and sign up to win tickets to the Superbowl (something that
had never been done with a drug before).
However, the macho man campaign didn't work so well,
so they dumped Ditka. Then they switched to a 40-something
year old brunette woman who says something like :
" Do you want to know little secret? Then she tells
you all about how great Levitra is".
Now the Levitra advertisements focus on a more subtle effect. They differentiate it by releasing information regarding its effectiveness in people with diabetes, hypertension and other ailments common to middle aged menfolk.
The Levitra advertisements and propotional materials use a candle as a metaphor for intimacy and passion.
The BIG Discovery
Some very smart scientists discovered that cyclic
guanosine monophosphate (cGMP) was the key to sustaining
an erection.
They discovered that when a man gets sexually stimulated,
a chain reaction occurs in the tissue of the penis that results
in elevated levels of a substance called cyclic guanosine
monophosphate (cGMP).
As long as there are sufficient levels of cGMP, the penis can
remain erect. The more cGMP, the more robust and durable
the erection.
If you inhibit the degradation of cGMP it stays around in the
penis longer, producing a more durable erection.
Another way you can think of Levitra (and all other similar
medicines) is that it preserves the elevated levels of cGMP
that are created when a man is sexually stimulated for a
stronger, more lasting erection.
That's how Levitra works - Levitra blocks the enzyme
phosphodiesterase-5 (PDE5) which is responsible for the
neutralization of cGMP. Levitra (Vardenafil) is a highly
selective inhibitor of PDE5. (PDE5 is not the only
phosphodiesterase involved in the erectile physiology
but it appears to be the most important one).
The nice thing about PDE5 blockers is that they shouldn't
cause erections at inappropriate times because they only
block degradation of cGMP produced in reaction to sexual
stimulation, such as thinking about something sexy. If you
are not being sexually stimulated, there is no cGMP to
protect, so the drug remains in the background.
Levitra Information On The Internet:
Recent Scientific Trial Regarding Levitra (vardenafil) versus Cialis (tadalafil) & Viagra (Sildenafil) regarding effects on pulmonary smooth muscle tissue (in an animal model).
Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets. … Sildenafil and tadalafil did not affect the phenylephrine-induced contractions, whereas vardenafil reduced the maximal responses … results indicate that vardenafil, in contrast to sildenafil or tadalafil, also blocked Ca(2+) fluxes, thus enhancing its vasorelaxation of the pulmonary artery …[ British Journal of Pharmacology (2008) 154, 787-796; doi:10.1038/bjp.2008.141; published online 21 April 2008]
Levitra Price Comparison: There is a lot of competition
between sites that sell Levitra. This competition drives
down the prices.
Our editors have searched the internet. Here are the top
10 internet websites that sell Levitra. You can get a real
good deal on Levitra if you comparison shop
See Also> Top 10 websites that sell Levitra
Levitra Versus Viagra From Forbes magazine 10/06/03;
by M. Herper and A. Lagorce; Side by side comparison
of various characteristics; cost, pharmacokinetics,
spokesperson, marketing, etc.
Levitra.com
Geared to patients; all about Levitra and erections,
including an illustrated picture of how an erection works;
also contains information on what to expect once you take
the pill.
Official Levitra Prescribing Information
(Package Insert); dose, mechanism of action, side effects,
precautions, warnings; patient information; very technical,
don't get scared when you come to the section on warnings
and side effects. [ This information is provided as a PDF
document. You will need Adobe Acrobat to view this information]
Levitra Patient Information
Who should take Levitra, who should avoid Levitra,
drug interactions, warnings, cautions, drug interactions.
Levitra Scientific Papers ( from the National Library of
medicine) automated Medline search; a listing of scientific
papers in abstract form regarding Levitra.
Levitra News (from Google) ; recently published news
regarding Levitra.
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